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  1. MCAS is an immunological condition in which mast cells inappropriately and excessively release chemical mediators, resulting in a range of chronic symptoms, sometimes including anaphylaxis or near-anaphylaxis attacks. Primary symptoms include cardiovascular, dermatological, gastrointestinal, neurological and respiratory problems.
    en.wikipedia.org/wiki/Mast_cell_activation_syndrome
    en.wikipedia.org/wiki/Mast_cell_activation_syndrome
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    Mast cell activation syndrome - Wikipedia

    Mast cell activation syndrome (MCAS) is a term referring to one of two types of mast cell activation disorder (MCAD); the other type is idiopathic MCAD. MCAS is an immunological condition in which mast cells inappropriately and excessively release chemical mediators, resulting in a range of chronicVisa mer

    MCAS can present with a wide range of symptoms in multiple body systems, these symptoms may range from digestive discomfort to chronic pain, mental issues as well as an anaphylactic reaction. Symptoms typically … Visa mer

    There are many causes of mast cell activation, including allergy. Genetics may play a role. In particular, Mutations of the KIT gene (which codes for the KIT protein that regulates cell growth and specifically), specifically around codon 816 with the common one being … Visa mer

    Pharmacological treatments include:
    Mast cell stabilizers, including cromolyn sodium and natural stabilizers such as quercetin Visa mer

    The condition was hypothesized by the pharmacologists Oates and Roberts of Vanderbilt University in 1991, and named in 2007, following a … Visa mer

    1991
    Mast cell activation syndrome was hypothesized by the pharmacologists Oates and Roberts of Vanderbilt University.
    2007
    Mast cell activation syndrome was named following a build-up of evidence featured in papers by Sonneck et al. and Akin et al.
    2010
    Diagnostic criteria for MCAS was formalized.
    2016
    Mast cell activation was assigned an ICD-10 code (D89.40, along with subtype codes D89.41-43 and D89.49).
    2019
    Diagnostic criteria for MCAS was revised.

    Mast cell activation can be localized or systemic, but a diagnosis of MCAS requires systemic symptoms. Some examples of tissue … Visa mer

    MCAS is often difficult to identify due to the heterogeneity of symptoms and the "lack of flagrant acute presentation". Many of the numerous … Visa mer

    The prognosis of MCAS is uncertain. Visa mer

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