Prodrug - Wikipedia
WebbA prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted .
Lisdexamfetamine - Wikipedia
WebbLisdexamfetamine is an inactive prodrug that works after being converted by the body into dextroamphetamine, a central nervous system (CNS) stimulant. Chemically, lisdexamfetamine is composed of the amino acid L-lysine, attached to dextroamphetamine.
Prodrug – Wikipedia
WebbEt prodrug er et legemiddel som er inaktivt i den formen som den tas. Når legemiddelet har kommet inn i kroppen omformes det til den aktive formen. Omformingen skjer ved at en del av legemiddelets kjemiske struktur forandres. Prodrugs er legemidler som virker via aktive metabolitter som dannes via spesielle enzymer.
Promethazine - Wikipedia
WebbKey:PWWVAXIEGOYWEE-UHFFFAOYSA-N Y. (verify) Promethazine, sold under the brand name Phenergan among others, is a first-generation antihistamine, antipsychotic, sedative, and antiemetic used to treat allergies, insomnia, and nausea.
プロドラッグ - Wikipedia
Webbプロドラッグ（英: Prodrug ）とは、投与されると生体による代謝作用を受けて活性代謝物へと変化し、薬効を示す医薬品である 。
Prodrug – Wikipedia
WebbAls Prodrug (das oder die Prodrug), auch Propharmakon, wird ein inaktiver oder wenig aktiver pharmakologischer Stoff bezeichnet, der erst durch Verstoffwechselung (Metabolisierung) im Organismus in einen aktiven Wirkstoff (Metaboliten) überführt wird.
Newly Developed Prodrugs and Prodrugs in Development; an …
Webb17 feb. 2020 · Many prodrugs have enjoyed clinical success in treating various chronic and acute conditions [ 1 ]. Among the successful examples are the prodrugs indented for the management of hypertension such as the angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs).
Prodrug - an overview | ScienceDirect Topics
WebbProdrug is a compound with little or no pharmacological activity that metabolizes inside the body and converts into a pharmacologically active drug compound. Prodrugs are designed to overcome pharmaceutical, pharmacokinetic, and/or pharmacodynamic challenges.
The landscape of small-molecule prodrugs - Nature
Webb2 apr. 2024 · We highlight rationales that underlie prodrug design, their indications, mechanisms of API release, the chemistry of promoieties added to APIs to form prodrugs and the market impact of prodrugs.
Prodrugs for Improved Drug Delivery: Lessons Learned from …
Webb29 okt. 2020 · The prodrug approach is used for the optimization of newly discovered chemical entities, as well as to improve the properties of already marketed drugs. The United States Food and Drug Administration (FDA) have approved around 30 prodrugs in the past decade (12% of all approved new small-molecule entities).
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