Tyson would put his guard up high, with both of his gloves just slightly covering his cheekbones to fully protect the chin while not sacrificing line of sight. This is coupled with side-to-side head movement, bobbing, weaving, and lateral footwork. Tyson would then use his momentum to generate the power in his hooks and uppercuts.

Tyson is a left-handed fighter who chooses to adopt the orthodox stance to fight. This is an uncommon practice, as most fighters have their weaker side closer to their opponent. Although Mike Tyson could easily switch stances, the former heavyweight champion preferred to jab with his left hand.