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Se alt på WikipediaProdrug - Wikipedia
A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, … Se mer
Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the … Se mer
Approximately 10% of all marketed drugs worldwide can be considered prodrugs. Since 2008, at least 30 prodrugs have been approved by the Se mer
1897Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid.1909The first synthetic antimicrobial drug, arsphenamine, discovered in 1909 by Sahachiro Hata in the laboratory of Paul Ehrlich, is not toxic to bacteria until it has been converted to an active form by the body.1932Prontosil, the first sulfa drug (discovered by Gerhard Domagk in 1932), must be cleaved in the body to release the active molecule, sulfanilamide.2008Since 2008, at least 30 prodrugs have been approved by the FDA.2010Dabigatran etexilate was approved in 2010.2011Gabapentin enacarbil was approved in 2011.2013Sofosbuvir was approved in 2013.2014Tedizolid phosphate was approved in 2014.2015Seven prodrugs were approved in 2015.2015Aripiprazole lauroxil was approved in 2015.Prodrugs can be classified into two major types, based on how the body converts the prodrug into the final active drug form:
• Type I prodrugs are bioactivated inside the cells … Se merWikipedia-tekst under CC-BY-SA-lisens Lisdexamfetamine - Wikipedia
Lisdexamfetamine, sold under the brand names Vyvanse and Elvanse among others, is a stimulant medication that is used to treat attention deficit hyperactivity disorder (ADHD) in children and adults and for moderate-to-severe binge eating disorder in adults. Lisdexamfetamine is taken by mouth. Its effects generally begin within two hours and last for up to 14 hours. In the United Kingdom, it i…
Wikipedia · Tekst under CC-BY-SA-lisens- Beregnet lesetid: 9 min
Prodrug – Wikipedia
NETTETEt prodrug er et legemiddel som er inaktivt i den formen som den tas. Når legemiddelet har kommet inn i kroppen omformes det til den aktive formen. Omformingen skjer …
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Promethazine - Wikipedia
NETTETKey:PWWVAXIEGOYWEE-UHFFFAOYSA-N Y. (verify) Promethazine, sold under the brand name Phenergan among others, is a first-generation antihistamine, antipsychotic, sedative, and antiemetic …
プロドラッグ - Wikipedia
NETTETプロドラッグ（英: Prodrug ）とは、投与されると生体による代謝作用を受けて活性代謝物へと変化し、薬効を示す医薬品である 。
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Prodrug – Wikipedia
NETTETAls Prodrug (das oder die Prodrug), auch Propharmakon, wird ein inaktiver oder wenig aktiver pharmakologischer Stoff bezeichnet, der erst durch Verstoffwechselung …
Newly Developed Prodrugs and Prodrugs in Development; an …
NETTET17. feb. 2020 · Many prodrugs have enjoyed clinical success in treating various chronic and acute conditions [ 1 ]. Among the successful examples are the prodrugs …
Prodrug - an overview | ScienceDirect Topics
NETTETProdrug is a compound with little or no pharmacological activity that metabolizes inside the body and converts into a pharmacologically active drug compound. Prodrugs …
The landscape of small-molecule prodrugs - Nature
NETTET2. apr. 2024 · We highlight rationales that underlie prodrug design, their indications, mechanisms of API release, the chemistry of promoieties added to APIs to form …
Prodrugs for Improved Drug Delivery: Lessons Learned from …
NETTET29. okt. 2020 · The prodrug approach is used for the optimization of newly discovered chemical entities, as well as to improve the properties of already marketed drugs. …
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